See below for the Cause of Gray Hair
Circadian Rhythms of Disease and Timing Taking of Medications
Our bodies have a natural 24-hour cycle called the circadian rhythm. This rhythm affects many of our bodily functions, including our sleep-wake cycle, body temperature, and hormone levels. Timing our meds help them do their job better.
Diseases can also have a circadian rhythm. This means that they tend to flare up or worsen at certain times of day. For example, asthma symptoms often worsen in the early morning, and heart attacks are more likely to occur in the morning.
Understanding the circadian rhythm of diseases can help doctors to better diagnose and treat these conditions. For example, doctors may prescribe medications that are more effective at certain times of day. They may also recommend lifestyle changes that can help to improve the body’s natural circadian rhythm.
Why is Timing So Important When Taking Medication?
The timing of medications can affect how well they work. Some medications are more effective when taken with food, while others should be taken on an empty stomach. This timing can also affect the absorption and metabolism of medicines.
For example, the antibiotic ciprofloxacin is more effective when taken with food. This is because food helps to increase the absorption of medication. The blood pressure medication lisinopril, on the other hand, should be taken on an empty stomach. This is because food can interfere with the absorption of the medication.
It is important to follow your doctor’s instructions carefully when it comes to medication timing. Taking medications at the wrong time can reduce their effectiveness or increase the risk of side effects.
What are the Risks or Losses of Taking All Medications Together?
If you take multiple medications at the same time it can increase the risk of side effects and drug interactions. Some medications can also interfere with the absorption or metabolism of other medications.
For example, the blood thinner warfarin can interact with the antibiotic clarithromycin. This interaction can increase the risk of bleeding.
It is important to talk to your doctor about how to space out your medications to minimize the risk of side effects and drug interactions.
How Do You Determine Medication Interactions?
There are a number of ways to determine if there are any potential medication interactions.
· Your doctor can check for interactions when they prescribe a new medication.
· You can also use a medication interaction checker online or in a drug reference book.
· When using a medication interaction checker, it is important to enter all of the medications you are taking, including over-the-counter medications and supplements.
What is the Circadian Rhythm of Diseases?
Many diseases have a circadian rhythm, meaning that they tend to flare up or worsen at certain times of day.
The circadian rhythm of diseases is thought to be caused by changes in the body’s hormones, metabolism, and immune system throughout the day.
For example, asthma symptoms often worsen in the early morning. This is because the body’s production of cortisol, a hormone that helps to control inflammation, is lower in the morning.
Heart attacks are also more likely to occur in the morning. This is because the body’s heart rate and blood pressure are higher in the morning.
Understanding the circadian rhythm of diseases can help doctors to better diagnose and treat these conditions. For example, doctors may prescribe medications that are more effective at certain times of day. They may also recommend lifestyle changes that can help to improve the body’s natural circadian rhythm.
Regulating Light While Sleeping Has an Effect
A study found that exposure to light at night can suppress the body’s production of melatonin, a hormone that plays a role in regulating sleep. This suppression of melatonin can make breast cancer cells more resistant to tamoxifen, a common breast cancer drug. The study also found that sleeping in complete darkness can help to improve the effectiveness of tamoxifen. Lights can penetrate the eyelids and disrupt and effect melatonin production. Light is not just from a bedside table lamp, but can be a television or computer screens.
Here are some additional tips for taking medications safely:
· Always follow the directions on your medication label.
· Do not take more medication than prescribed.
· Don’t take medication that has expired.
· Store medication properly.
· Talk to your doctor or pharmacist if you have any questions about your medication.
By following these tips, you can help to ensure that you are taking your medications safely and effectively.
The timing of medications can be important for both their effectiveness and safety. By understanding the circadian rhythm of diseases and the timing of medications, doctors can better diagnose and treat these conditions. Patients can also take steps to ensure that they are taking their medications safely and effectively.
LINKS
- https://slate.com/technology/2007/11/when-during-the-day-should-you-take-your-medication.html ; When during the day should you take your medication? NOV 01, 2007
- https://www.rd.com/list/medication-timing/ The Right Time to Take 15 Daily Medications; May 09, 2023
- https://www.aarp.org/health/drugs-supplements/info-12-2013/timing-of-daily-medications-key.html Timing When to Take Your Daily Medications; December 2013
GRAYING HAIR
Gray hair is a natural part of aging for most people. However, some people may experience premature graying, which can be caused by a variety of factors. There are a number of options available for people who want to address gray hair, including hair coloring products, hair treatments, and lifestyle changes.
The Challenge
The issue is that hair turns gray due to a build-up of hydrogen peroxide in hair follicles. That reaction causes hair to bleach itself from the inside out. This is a problem because it can lead to people feeling self-conscious about their appearance. It can also be a sign of aging, which can be upsetting for some people. The need to solve this problem has been driven by the desire to find a way to prevent or reverse graying hair. There are many people who would like to keep their hair looking its natural color for as long as possible.
Available Options
A number of options are available for people who want to prevent or reverse graying hair. These include:
Hair dye: This is the most common option. Hair dye can cover up gray hair, but it does not address the underlying problem.
Home remedies: There are a number of home remedies that claim to prevent or reverse graying hair. However, there is no scientific evidence to support these claims.
Medications: There are a few medications that are available to treat graying hair. However, these medications can have side effects.
Hair coloring products: Hair coloring products are the most common way to cover gray hair. They come in a variety of shades and formulas, and they can be applied at home or by a professional.
Treatments for hair: There are a number of hair treatments that claim to prevent or reverse gray hair. However, there is limited scientific evidence to support these claims.
Lifestyle changes: There are a number of lifestyle changes that may help to slow the progression of gray hair. These include eating a healthy diet, exercising regularly, and managing stress.
Pseudocatalase is a new treatment for graying hair. It is a modified enzyme that helps to break down hydrogen peroxide. Pseudocatalase is still in development, but early studies have shown promise. It is not clear whether pseudocatalase is safe or effective for everyone. More research is needed to determine the long-term effects of pseudocatalase. Pseudocatalase is taken or applied topically. It is not yet available for purchase, but it is expected to be available in the future. The first study on pseudocatalase was published in 2013. The study found that pseudocatalase was effective in reversing graying hair in mice.
Potential Solutions in Development
In addition to pseudocatalase, there are a number of other potential solutions to gray hair that are currently under development. These include:
Stem cell therapy is a promising new treatment that may be able to regrow hair follicles and restore hair color. https://nyulangone.org/news/study-links-stuck-stem-cells-hair-turning-gray Study Links ‘Stuck’ Stem Cells to Hair Turning Gray; APRIL 19, 2023
Gene therapy is another promising new treatment that may be able to target the genes responsible for gray hair. https://www.uab.edu/reporter/research/discoveries-innovations/item/8990-going-gray-isn-t-a-one-way-trip-uab-researcher-exploring-ways-to-rejuvenate-gray-hairs Going gray isn’t a one-way trip? UAB researcher exploring ways to ‘rejuvenate’ gray hairs; The University of Alabama at Birmingham; January 23, 2020
Pseudocatalase is still in development. There have been a number of studies conducted on pseudocatalase, and the results have been promising. https://www.sciencedaily.com/releases/2013/05/130503132958.htm; Gray hair and vitiligo reversed at the root; May 3, 2013
Pseudocatalase is currently available as a topical treatment. It is applied to the scalp twice daily. It is helpful in counteracting the effects of Vitiligo which is a chronic (long-lasting) autoimmune disorder that causes patches of skin to lose pigment or color.
While there is certainly, a hungry market for whatever becomes the solution, there are some who are tapping the brakes of enthusiasm.
LINKS
https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.08-125435 Senile hair graying: H202 medicated oxidative stress affects human hair color by blunting methionine sulfoxide repair
https://www.sciencedaily.com/releases/2009/02/090223131123.htm Why Hair Turns Gray Is No Longer A Gray Area: Our Hair Bleaches Itself As We Grow Older; February 24, 2009
https://www.medicalnewstoday.com/articles/260089#1 Cure For Gray Hair And Vitiligo Found; July 13, 2015
